Optimized synthesis of O-carboxymethyl-N,N,N-trimethylamino chitosan
نویسندگان
چکیده
We present here the synthesis of a highly O-carboxymethylated chitosan derivative. First, an improvedprotocol for the two-step synthesis of N-trimethyl chitosan (TMC) from chitosan was developed, yield-ing a maximum degree of quaternization (DQ) of up to 46.6%. Successively, the chitosan derivativeO-carboxymethyl-N-trimethyl chitosan (CMTMC) was synthesized from the TMC obtained by applyingan optimized synthesis pathway. In contrast to previous reports, the optimized protocol was shown toyield very high rates (>85%) of O-carboxymethylation of CMTMC, as shown by1H NMR and heteronu-clear single quantum correlation (1H–13C HSQC). Finally, in vitro cytocompatibility (viability >80%) of thepolymer was demonstrated using human fibroblasts. PATRULEA, Viorica, et al. Optimized synthesis of O-carboxymethyl-N,N,N-trimethyl chitosan. Carbohydrate Polymers, 2015, vol. 122, p. 46-52 DOI : 10.1016/j.carbpol.2014.12.014
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